![]() ![]() Your nurse will give you extra calcium through a drip if this happens. This happens if your calcium level gets low during your collection. You might feel very tired after having your stem cell collection. They are collected and frozen until after your high dose treatment. The machine filters the stem cells out of your blood. It goes through the machine and back into your body through the other drip. Your nurse puts a drip into each of your arms and attaches it to a machine. Collecting the stem cells takes 3 or 4 hours. When there are enough cells, your nurse collects them. On the collection dayĪfter your growth factor injections, you have blood tests every day to see if there are enough stem cells in your bloodstream. Sometimes you might have low doses of chemotherapy with the growth factor injections. You have daily injections of growth factor for between 5 and 10 days. Growth factors are natural proteins that make the bone marrow produce blood cells. You have injections of growth factors before, and sometimes after, the stem cell transplant. In some cancer centres, you may stay at home or in a hotel near the hospital for some of this time. It depends on your individual situation, including how quickly your blood cells recover and how well you are. You may stay in hospital for a few weeks after a stem cell transplant. Find out what happens when you have a stem cell transplant.Platelets help to clot the blood to prevent bleeding. White blood cells are part of your immune system and help to fight infection. Red blood cells contain haemoglobin which carries oxygen around the body. These stem cells develop into red blood cells, white blood cells and platelets. Stem cells are very early cells made in the bone marrow. Bone marrow is a spongy material that fills the bones. Your specialist will talk through the options with you. ![]() The most appropriate use of induction therapy, 1-8 autologous stem-cell transplantation (ASCT), 1,9 and maintenance therapy 5. Stem cell transplants are very intensive treatments, and can cause severe side effects. Triplet Therapy, Transplantation, and Maintenance in Myeloma. Remission means that there is no sign of active myeloma. Your doctor might recommend intensive treatment to improve the chance of getting a complete response, which is called CR or remission. Why you might have a stem cell transplant They are sometimes called stem cell rescue or intensive treatments. This is called having a stem cell transplant. All rights reserved.High dose chemotherapy destroys cancer cells, but also damages the stem cells that make blood cells in the bone marrow. So if you need high dose treatment you need a way of replacing the stem cells that have been destroyed. Novel targeted agents are currently being investigated in both the upfront and relapse settings, but to date there are few data to suggest durable treatment responses that compare favorably with results of transplantation.Īutologous stem cell transplant Cytarabine High dose Mantle cell lymphoma Rituximab.Ĭopyright © 2017 Elsevier Inc. We argue that consolidative autologous stem cell transplantation in first remission remains the standard of care for the young and fit patient population, based on long-term data from phase II and III trials demonstrating that early transplantation extends both progression-free and overall survival. There are currently few reliable prognostic markers, making it difficult to accurately predict which patients require early intensive treatment. It is a heterogeneous disease, and although most patients experience an aggressive clinical course, some have a more indolent disease and may not require immediate therapy. Mantle cell lymphoma is a relatively rare malignancy, comprising fewer than 10% of all non-Hodgkin lymphomas. ![]()
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